Controlled comparative study for nutritional improvement among branched chain amino acids(BCAA),general liquid nutrient and BCAA-rich nutrient during endscopic treatment of esophageal varices.

Controlled comparative study for nutritional improvement among branched chain amino acids(BCAA),general liquid nutrient and BCAA-rich nutrient during endscopic treatment of esophageal varices. - Controlled comparative study for nutritional improvement among BCAA,general liquid nutrient and BCAA-rich nutrient during endscopic treatment of esophageal varices.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001534

Enrollment

100

Registered

2008-11-30

Start date

2008-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

esophageal varices

Interventions

Patients without BCAA before this study. This group reseives no additional nutrient during whole period of this study.(GroupA) Patients without BCAA before this study. This group reseives two pack

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.patients with esophageal varices who will receive endscopic therapy. 2.patients who understand the study contents and give informed consents by themselves.

Exclusion criteria

Exclusion criteria: 1.patients who took regular administration of albumin products more than once a week for one month. 2.patients with severe disorder of glucose metabolism. 3.patients with severe renal failure. 4.patients with congenital disorder of amino-acid metabolism. 5.patients who are regarded in-eligible by the doctor who participates in this study.

Design outcomes

Primary

Measure	Time frame
1.The rate of improvement in nutritional metabolism using indirect calorimetry The starting date of study is defined as day0, and endscopic therapies are conducted on day0,day7 and day14. The rate of improvement in non-protein respiratory quotient(npRQ) using indirect calorimetry are evaluated every therapic day.	—

Secondary

Measure	Time frame
1.The rate of improvement by Subjective Global Assessment The rate of improvements in subjective symptom and physical measurement are evaluated on day0,day7,day14,and day56. 2.The transition of serum protein The transitional changes of serum albumin, pre-albumin, retinol-binding protein(RBP), branched chain amino acid & tyrosine ratio(BTR) are evaluated on day0,day7,day14,and day56. 3.The changes of glucose tolerance Glucose tolerance in fasting blood sugar,immunoreactive insulin(IRI) are evaluated on day0,day7,day14,and day56	—

Measure

Time frame

1.The rate of improvement by Subjective Global Assessment The rate of improvements in subjective symptom and physical measurement are evaluated on day0,day7,day14,and day56. 2.The transition of serum protein The transitional changes of serum albumin, pre-albumin, retinol-binding protein(RBP), branched chain amino acid & tyrosine ratio(BTR) are evaluated on day0,day7,day14,and day56. 3.The changes of glucose tolerance Glucose tolerance in fasting blood sugar,immunoreactive insulin(IRI) are evaluated on day0,day7,day14,and day56

—

Countries

Japan

Contacts

Public Contactyshiyuki sakai

Hyogo College of Medicine Department of Internal Medicine Division of Hepatobiliary and Pancreatc Disease

sakai429@hotmail.com0798-45-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026