Dementia with Lewy bodies (DLB), Parkinson disease with dementia (PDD)
Conditions
Interventions
Four weeks of conventional dose of YKS treatment
Sponsors
yokukansan-DLB research group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Probable DLB patients diagnosed according to the international consensus criteria for DLB. Parkinson's disease (PD) with dementia is also included. 2.Patients with 4 or more points at least one subscale of NPI 3.Serum potessium is within normal limit.
Exclusion criteria
Exclusion criteria: 1.Malignancy 2.Severe life-thretning disease such as heart, liver, renal, blood diseases. 3.Other type of dementia i.e. Alzheimer disease, vascular dementia, FTD. 4.Neurodegenerative disease other than DLB or PD. 5.Other mental disorders such as depression, bipolardisorder,schizophrenia. 6.Hallucination due to alcohol abuse, drug abuse and / or other reasons 7. Use of neuroleptics (i.e. fluphenazine, haloperidol) within rescent 4 weeks. 8.Diagnosed as inadequate by the physician in charge
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neuropsychiatric Inventry at baseline and after 2 and 4 weeks of YKS treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| MMSE, DAD, BEHAVE-AD, Zarit score, Fluctuation, biochemistry data at baseline and 4 weeks treatment | — |
Countries
Japan
Contacts
Public ContactShinji Ioka
Tsumura & Co. Devision of medical research
Outcome results
None listed