Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates

Pharmacogenetic study on the influence of aldehyde dehydrogenase 2 (ALDH2) gene polymorphism on the vasodilatation induced by organic nitrates - The influence of ALDH2 gene polymorphism on the effect of organic nitrates

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001492

Enrollment

Registered

2008-11-11

Start date

2008-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

angina pectoris

Interventions

nitroglycerin isosorbide dinitrate

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Older than 20 and younger than 39 Healthy volunteers Persons whose ALDH2 gene polymorphism is known

Exclusion criteria

Exclusion criteria: History of cardiovascular diseases Serious liver damages Serious renal damages Pregnant women History of adverse reaction to organic nitrates Persons using sildenafil, vardenafil, or tadalafil Systolic blood pressure less than 90 mmHg Body weight less than 40 kg or more than 90 kg Persons considered to be unsuitable to the study

Design outcomes

Primary

Measure	Time frame
Ratio of maximal increase in brachial artery diameter Time to attain maximal and 90% maximal dilatation of brachial artery	—

Secondary

Measure	Time frame
Pulse rate, blood pressure, and their post/pre-administration ratios	—

Countries

Japan

Contacts

Public ContactToshiyuki Sasaguri

Faculty of Medical Sciences, Kyushu University Department of Clinical Pharmacology

sasaguri@med.kyushu-u.ac.jp092-642-6080

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026