Kennedy-Alter-Sung syndrome (KAS)
Conditions
Interventions
Leuprorelin acetate (SR) 11.25mg subcutaneous infection per 12 weeks
Sponsors
Department of Neurology Chiba University Graduate School of Medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Genetically confirmed KAS patients with written informed concent, who have no desire to father achild, no severe disturbance in liver and renal functions, and can stand for 6 min.
Exclusion criteria
Exclusion criteria: "1) Patients who have taken any drugs which effect serum teststerone level within 48 weeks prior to the informed consent. 2) Patients who have taken any drugs which rduce serum teststerone level for more than 48 weaks prior to the informed concent. 3) Patients who have undergone surgical castration. 4) Patients with major depression. 5) Patients who have severe complications including sereve hypertention. 6) Patients who cannot undergo the clinical tests included in this trial. 7) Patients with allergy to leuprorelin acetate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pharyngeal barium residue in videofluorography | — |
Secondary
| Measure | Time frame |
|---|---|
| serum CK, parameters in videofluorography, frequency of 1C2 antibody staining in scrotal skin, clinical scores, clinical scores, QOL scores, parameters in electrophysiological testings | — |
Countries
Japan
Outcome results
None listed