A randomized controlled trial comparing anti-arrhythmic effect of landiolol hydrochloride in cardiac surgery

A randomized controlled trial comparing anti-arrhythmic effect of landiolol hydrochloride in cardiac surgery - PASCAL trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001442

Enrollment

200

Registered

2008-10-20

Start date

2008-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

myocardial infarction, angina, valvular disease, thoracic aortic aneurysm, arrhythmia

Interventions

intra-and perioperative administration of landiolol hydrochloride intra-and perioperative non-administration of landiolol hydrochloride

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients from whom informed consent was obtained

Exclusion criteria

Exclusion criteria: cardiogenic shock sinus bradycardia at rest (<50/min) second -or third-degree AV block clinical hypothyroidism or hyperthyroidism Doctor's decision not to register to this regimen

Design outcomes

Primary

Measure	Time frame
Incidence of postoperative arrhythmia	—

Secondary

Measure	Time frame
1) age 2) Blood pressure, heart rate, CVP 3) hyaluronan, KL-6, ANP, BNP, angiotensin-II	—

Countries

Japan

Contacts

Public ContactAkira Sezai

Nihon University school of medicine Department of Cardiovascular Surgery

asezai.med@gmail.com03-3972-8111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026