Correlation between prognosis and expressions of Mcl-1(Myeloid cell leukemia-1) and Stat-3(signal transducers and activator of transcription-3) in patients with metastasized or recurrent gastrointestinal malignancy

Correlation between prognosis and expressions of Mcl-1(Myeloid cell leukemia-1) and Stat-3(signal transducers and activator of transcription-3) in patients with metastasized or recurrent gastrointestinal malignancy - Correlation between prognosis and expressions of Mcl-1 and Stat-3 in patients with metastasized or recurrent gastrointestinal malignancy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000001431

Enrollment

Registered

2008-11-01

Start date

2008-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Unresectable and recurrent gastric or colorectal carcinoma

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with unresectable and recurrent gastric or colorectal carcinoma who had agreed to recieve chemotherapy at Keio University Hospital.

Exclusion criteria

Exclusion criteria: Patient who is not willing to join the study

Design outcomes

Primary

Measure	Time frame
Relationships between explession levels of apoptosis related proteins ( Mcl-1, Phospho-Stat3, Bcl-2, Bcl-xl, Bcl-xs, cIAP, cFLIP) and efficacy of chemotherapy.	—

Secondary

Measure	Time frame
Expression level of apoptosis related protein and background of patients, pathological characters, location and types of cancers.	—

Countries

Japan

Contacts

Public ContactMotoko Izumiya, MD

Keio University School of Medicine Department of Gastroenterology and Hepatology

03-3353-1211

Outcome results