Neurogenic detrusor overactivity
Conditions
Interventions
After solving Botulinum toxin A 200 units by normal saline 15ml, 30 subepithelial injections avoiding injection into trigone are performed.
Sponsors
National Center for Geriatrics & Gerontology
Tokyo University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patient suffered from spinal cord injury. 2) Detrusor overactivity was confirmed by cystometrogram. 3) Written informed consent is required. 4) One or more times a week of urge/reflex urinary incontinence was seen after antichorinergic drugs or antichorinergic drugs could not be continued because of adverse effects.
Exclusion criteria
Exclusion criteria: 1) The patient underwent the surgery such as bladder augmentation. 2) The patient underwent the treamtment using botulinum toxin A. 3) The patient underwent the surgery of lower urinary tract within 1 year. 4) The patient had symptomatic urinary tract infection, malignancy and bladder stone. 5) The patient is pregnant or breast-feed, or have possibility of such matter within 1 year. 6) The patient is diagnosed as having myasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis. 7) The patient has disturbance of swallowing and/or respiration. 8) The patient has mental and/or cognitive disturbance to conduct clinical trial. 9) The patient is judged as being unsuitable for the trial by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of the number of urge/reflex urinary incontinence 1month after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Recurrence of urge/reflex urinary incontinence, change of bladder capacity after treatment | — |
Countries
Japan
Contacts
Public ContactKikuo Okamura
National Center for Geriatrics & Gerontology Division of Urology, Department of Surgery & Intensive Care
Outcome results
None listed