The efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma

The efficacy and safety of autologous gamma/delta T cell transfer therapy for extrahepatic metastasis of hepatocellular carcinoma - Autologous gamma/delta T cell therapy for extrahepatic metastasis of hepatocellular carcinoma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001418

Enrollment

Registered

2008-10-08

Start date

2008-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Extrahepatic metastasis of hepatocellular carcinoma

Interventions

Gamma/delta T cells are injected on day0, day7, day14, day21, day35, day49, day63, day77.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Hepatocellular carcinoma patients who have extrahepatic metastasis: - Pathological diagnosis of hepatocellular carcinoma; - Diagnosis of extrahepatic metastasis by imaging; - Life-expectancy is more than 3 months; - Performance status is 0-1; - No serious abnormality in heart, lung, bone marrow, liver, and renal functions.

Exclusion criteria

Exclusion criteria: Patients who have: - Pulmonary fibrosis or interstitial pneumonia, including their history or predisposition of them; - Active enteritis, - Active autoimmune diseases, - Active infections; - Other cancers; - Other serious complications; - Continuous systemic administration of steroids.

Design outcomes

Primary

Measure	Time frame
Progression- free survival	—

Secondary

Measure	Time frame
Overall survival Response rate Survival rate (1 and 2 years) Response of tumor-related markers Immunological responses Safety	—

Countries

Japan

Contacts

Public ContactKazuhiro Kakimi

Graduate School of Medicine, The University of Tokyo Department of Immunotherapeutics

immunotherapy-admin@umin.ac.jp03-5805-3161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026