Hypertension
Conditions
Interventions
Losartan/hydrochlorothiazide group
High-dose ARB group
Sponsors
Kobe hypertensive study group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria:1) Hypertensive patients, who have been previously treated with monotherapy of an ARB or ARB and Carcium channel blocker for more than 8 weeks, however, whose blood pressure has not been reached the target defined by the JSH2004 criteria.2) Men and women aged more than 20 years 3) Outpatients4) Patients who fully understand the study procedures explained to them using explanatory notes and have given written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria:1) Patients with uncontrolled hypertension (diastolic blood pressure under 110mmHg) 2) Patients with secondary hypertension 3) Patients with uncontrolled diabetes (HbA1c over 8.0%) and under treatment with insulin 4) Patients who have stroke, AMI and/or other critical vascular complications that required hospitalization within 3 months prior to the intervention 5) Patients with liver dysfunction [GPT(ALT) over three times the normal value]6) Patients with renal failure (serum creatinine over 2.0 mg/dL)7) Patients with a previous history of gout attack or uncontrolled hyperuricemia (over 8.0mg/dL)8) Patients with cardiac insufficiency (NYHA grade III )9) Patients with severe malignant cancer or other unfavorable prognostic factors10) Pregnant or possible pregnant women11) Patients , who have been previously treated with diuretics 12) Patients with a history of hypersensitivity to ingredients of losartan potassium or hydrochlorothiazide13) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics13) Patients with a history of hypersensitivity to ingredients of a calcium channel blocker to be used in the study14) Patients who are considered not eligible for the study by the attending doctor due to medical reasons
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in blood pressure level measured on an outpatient basis after 12 weeks of treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| - Change in blood pressure level measured on an outpatient basis after 24,48 weeks of treatment- Changes in blood pressure level at home after getting up,ABPM,NT-proBNP,hs-CRP,PAI-1,Aldosterone after 12, 24 and 48 weeks of treatment- Change in catroid internal-medical thickness after 48 weeks of treatment | — |
Countries
Japan
Contacts
Public ContactRyuji Toh
Kobe University Graduate School of Medicine Division of Cardiovascular Medicine
Outcome results
None listed