Community-acquired pneumonia
Conditions
Interventions
cefotiam 1g IV, every 12 hrs, for 4-14 days. Clarithromycin 200mg PO, bid, for 4-14 days. May be adjusted when renal failure.
ampicillin/sulbactam 3g IV, every 12 hrs, for 4-14 days. Clarithrom
Sponsors
Ono Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Patients with community-acquired pneumonia aged 15 yrs or more (2) Radiological appearance of a new and/or progressive pulmonary infiltrate(s) (3) At least two of the followings: cough, sputum or change of sputum character (increased volume and/or purulence), dyspnea, tachypnea, abnormal breathing sound (wheeze etc.), pleuritic chest pain, auscultatory findings on chest examination consistent with the lung infiltrate, documented axillary body temperature > or = 37.5C within the past 24hrs, rigors and/or chills, general malaise, and a WBC count of > or = 10,000/mm3 or < 3,000/mm3.
Exclusion criteria
Exclusion criteria: (1) Hospital-acquired pneumonia (2) Hospitalization within 60 days prior to the development of the symptom(s) (3) Immunocompromising disease or receipt of immunopompromising therapy (4) Active lung cancer (5) Terminal illness (6) Pregnancy or breast-feeding (7) Known allergy to the indicated antibiotics (8) Other infiltrative diseases (e.g. radiation pneumonitis, organizing pneumonia, drug-induced pneumonia, obstructive pneumonia etc.) (9) Tuberculosis, fungal infection (10) Empyema (11) Aspiration pneumonia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical response at the end of therapy, days 11-14 | — |
Secondary
| Measure | Time frame |
|---|---|
| Early clinical response at days 4 and 7 Bacteriological response at days 11-14 (in bacteriologically evaluable patients) Survival at day 30 | — |
Countries
Japan
Contacts
Public ContactSeizo Kadowaki
Ono Municipal Hospital Department of Internal Medicine
Outcome results
None listed