Unresectable advanced/recurrent colorectal cancer
Conditions
Interventions
Sponsors
KSCC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.colorectal cancer, cytologically and/or histrogically, and Unresectable advanced/recurrent colorectal cancer 2.2nd-line after FOLFOX base chemotherapy 3.the last prior therapy before more than 2 weeks of registration 4.no prior radiotherapy 5.age: 20-75 years old 6.Performance Status (ECOG): 0-2 7.with measurable lesions 8.Life expectancy estimated >= 3 months 9.Sufficient organ functions 10.witten informed consents
Exclusion criteria
Exclusion criteria: 1. Administering antithrobotic drug within 7 days 2. Serious complications (renal failure or hepatic failure) 3. Serious drug hypersensitivity or a history of drug allergy 4. Active concomitant malignancy 5. Active infections 6. High blood pressure and diabetic that cannot be controlled 7. symptomatic or asymptomatic but treated heart disease 8. interstitial pnumonitis, pulmonary fibrosis or high-grade pulmonary emphysema 9. histry of mental disturbances or cerebrovascular attach 10. Fresh hemorrhage from digestive tube, intestines tube paralysis, intestinal obstruction and peptic ulcer 11. Plerral effusion, peritoneal fluid and pericardial fluid 12. Symptomatic brain metastasis 13. Water solubility diarrhea, in case of the patient who has a colostomy, diarrhea impairs daily life activity 14. Need to treatment with atazanavir sulfate or flucytosine 15. under coutinuous steroid therapy 16. Pregnant women, possibly pregnant women, wishing to become pregnant, and nursing mothers 17. on other clinical trial 18. Other conditions not suitable for this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RR | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety, PFS, OS | — |
Countries
Japan
Contacts
Public ContactKSCC
CReS KSCC
Outcome results
None listed