Basic and clinical research of pathogenesis of hip pain

Basic and clinical research of pathogenesis of hip pain - Basic and clinical research of pathogenesis of hip pain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000001335

Enrollment

Registered

2008-08-24

Start date

2008-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the hip Femoral neck fracture

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Osteoarthritis of the hip a. Past history of developmental dysplasia or acetabular dysplasia b. Severe pain and dysfunction c. Total hip arthroplasty d. Imformed consent about this study 2) Femoral neck fracture a. Without developmental dysplasia nor acetabular dysplasia b. Asymptomatic before injury c. Hip arthroplasty d. Imformed consent about this study

Exclusion criteria

Exclusion criteria: 1) Past history of hip trauma, osteonecrosis of the femoral head, rheumatoid arthritis, and rapidly destructive coxarthritis 2) Previous hip surgery 3) Heart failure, respiratory dysfunction, hepatic insufficiency, and renal failure 4) Unfavorable patient condition 5) Inappropriate patient

Design outcomes

Primary

Measure	Time frame
In basic research, synovium, limbus, femoral head and acetabulum are stained with neuron-specific class III beta-tubulin (TuJ-1), isolectin B4 (IB4), calcitonin gene-related peptide (CGRP), transient receptor potential (TRP), tromyosin receptor kinase (Trk), tumor necrosis factor-alpha (TNFa), nuclear factor-kappa B (NFkB), and p55TNF receptor. Qualitative and quantitative assessments are performed between osteoarthritis and femoral neck fracture. In clinical research, distribution and incidence of hip pain are evaluated as well as referred pain. Association of hip pain, immunohistchemistry, and image findings are analyzed.	—

Measure

Time frame

In basic research, synovium, limbus, femoral head and acetabulum are stained with neuron-specific class III beta-tubulin (TuJ-1), isolectin B4 (IB4), calcitonin gene-related peptide (CGRP), transient receptor potential (TRP), tromyosin receptor kinase (Trk), tumor necrosis factor-alpha (TNFa), nuclear factor-kappa B (NFkB), and p55TNF receptor. Qualitative and quantitative assessments are performed between osteoarthritis and femoral neck fracture. In clinical research, distribution and incidence of hip pain are evaluated as well as referred pain. Association of hip pain, immunohistchemistry, and image findings are analyzed.

—

Countries

Japan

Contacts

Public ContactNAKAMURA JUNICHI

Graduate School of Medicine, Chiba University Orthopaedic Surgery

shiken@office.chiba-u.jp043-226-2117

Outcome results