Type 2 diabetic nephropathy with Hypercholesterolemia
Conditions
Interventions
Pitavastatin treatment group
Pravastatin treatment group
Sponsors
Kyushu University Graduate School of Medical Science Department of Medicine and Bioregulatory Science
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Type 2 diabetes patients with diabetic nephropathy and hypercholesterolemia fulfilling one or more of the following criteria 1) Biopsy-proven diabetic nephropathy 2) Duration of diabetes more than 5 years 3) Diabetic retinopathy 2.At least on two occasions during the observation period (0 month excluded), urinary albumin/ creatinine ratio in the range of 30-600mg/g. 3.Hypercholesterolemia 4.Over 20 years of age 5.Outpatient
Exclusion criteria
Exclusion criteria: 1."Contraindications""Relative Contraindications""Absolute Contraindications for Coadministration" and "Relative Contraindications for Coadministration" for pitavastatin or pravastatin 2.Patients with hypothyroidism or inherited muscle disorder (muscular dystrophy etc.) and patients with a previous history of drug-induced myopathy 3.Non- diabetic nephropathy 4. Renal dysfunction (s-Cr over 1.5 mg/dl) 5.Urinary tract infection 6.Uncontrolled diabetes, defined as HbA1c>10.0% 7.Malignancy 8. Stroke 9. Heart failure (NYHA Class >= III) or myocardial infarction 10.Angina with symptom 11.Participating in clinical trials or clinical research 12.Judged as unsuitable for participating in this study by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in urinary albumin/creatinine ratio,Changes in eGFR | — |
Secondary
| Measure | Time frame |
|---|---|
| urinary albumin/creatinine ratio, serum creatinine , Urea nitrogen, serum cystein C, LDL-C,TC,TG,HDL-C,non HDL-C, 8-isoprostane, urinary L-FABP, urinary typeIV collagen | — |
Countries
Japan
Contacts
Public ContactToyoshi Inoguchi
Kyushu University Graduate School of Medical Science Department of Medicine and Bioregulatory Science
Outcome results
None listed