Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia

Relationships between electroencephalogram and plasma concentration of midazolam after induction of anesthesia - Midazolam and electroencephalogram

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001293

Enrollment

Registered

2008-12-01

Start date

2007-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing operations under general anesthesia, not limited to specific diseases

Interventions

After starting recoriding of electroencephalogram in the operating room, general anesthesia is induced with bolus midazolam of 0.2 mg/kg and the trachea is intubated. Blood is obtained from indwelling

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients undergoing operations of body surface or extremities under general anesthesia

Exclusion criteria

Exclusion criteria: 1) patients undergoing thoracotomy or lapalotomy, 2) patients with advanced hepatic or renal dysfunction, 3) taking cytochrome P4503A inducers or inhibitors preoperatively, 4) predicted difficulty in tracheal intubation, 5) receiving CYP3A inhibitors during anesthesia, 6) receiving medications affecting electroencephalogram

Design outcomes

Primary

Measure	Time frame
plasma concentration of midazolam, bispectral index, 95% spectral edge frequency	—

Countries

Japan

Contacts

Public ContactYutaka Oda

Osaka City University Graduate School of Medicine Department of Anesthesiology

06-6645-2186

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026