Asthma
Conditions
Interventions
Treatment for 8 weeks with montelukast 10 mg once daily
Sponsors
Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka university Graduate school of medicine
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1) Patients had the consent for the study 2) Patients have mild-to-moderate persistent asthma according to Japanese asthma guidelines in 2006 3) under 24 score of Asthma Control Test 4) Patients had used inhaled corticosteroids over 8 weeks.
Exclusion criteria
Exclusion criteria: 1) Patients with a history of hypersensitivity to montelukast 2) Patients on continuous therapy with oral corticosteroids 3) In-patients for asthma within one month prior to entry the study 4) Patients with complications that could affect the evaluation of efficacy, such as bronchiectasis. 5) Pregnant women and women suspected of being pregnant, breast-feeding women 6) Patients who physician judged "not eligible"
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Exhaled breath condensate(IL-4, RANTES, IL-8, TNF-a, IP-10, TGF-b, H2O2, sICAM1, Leukotrienes, etc.) Respiratory function (peak expiratory flow) | — |
Secondary
| Measure | Time frame |
|---|---|
| Asthma Control Test Asthma Quality of Life Questionnaire clinical and laboratory adverse experiences | — |
Countries
Japan
Contacts
Public ContactMitsuhiro Yoshida
Osaka university Graduate school of medicine Department of Respiratory Medicine, Allergy and Rheumatic Diseases
Outcome results
None listed