Hypertension
Conditions
Interventions
None listed
Sponsors
Hokkaido Clinical Hypertension Research Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Hypertensive patients for whom treatment with Preminent is planned since their blood pressure has not reached the target levels (SBP <140 mmHg and DBP <90mmHg; SBP <130 mmHg and DBP <80mmHg if patients are 65 years or younger, with chronic kidney disease or diabetes, or with a previous history of cardiovascular disease) 2)Men and women aged 20 years or older 3)Both outpatients and inpatients 4)Patients who fully understand study procedures and have given written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: 1)Patients with a history of hypersensitivity to ingredients of losartan/HCTZ 2)Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 3)Pregnant (positive on a urine pregnancy test prior to the study) or breast feeding female patients, including one trying to conceive pregnancy during the planned study period 4)Patients with sever liver dysfunction 5)Patients with anuria or on dialysis 6)Patients with acute renal failure 7)Patients whose sodium and potassium levels in body fluids are clearly decreased
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Change in office blood-pressure 2.Change in BNP and NT-proBNP levels 3.Change in microalbuminuria, proteinuria and renal function | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Frequency of cardiovascular events (fatal and non-fatal myocardial infarction, unstable angina, angina that required hospitalization, coronary revascularization, stroke etc) 2.Frequency of renal events (end-stage renal disease [ESRD], deterioration in renal function, etc) 3.Mortality 4.Rates of adverse events 5.Exploratory subgroup analysis | — |
Countries
Japan
Contacts
Public ContactHisako Fujimoto
H-LIFE research secretariat H-LIFE research secretariat
Outcome results
None listed