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To compare therapeutic effect of Glycyrrhizic Acid and H1-receptor antagonist for acute urticaria : a multicenter, prospective, single-blind, randomized controlled trial

To compare therapeutic effect of Glycyrrhizic Acid and H1-receptor antagonist for acute urticaria : a multicenter, prospective, single-blind, randomized controlled trial - To compare therapeutic effect of Glycyrrhizic Acid and H1-receptor antagonist for acute urticaria : a multicenter, prospective, single-blind, randomized controlled trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000001254
Enrollment
60
Registered
2008-07-17
Start date
2007-07-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute urticaria

Interventions

Intravenous H1-receptor antagonist (Chlorpheniramine Maleate) Glycyrrhizic Acid injestion

Sponsors

Yuzawa Community Medical Center
Lead Sponsor
Tsukuba Medical Center Hospital
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients who are newly diagnosed as an acute moderate or severe urticaria (defined by Japanese guideline); who has had no acute urticaria in 1 month before entry; and no condition requiring emergency management.

Exclusion criteria

Exclusion criteria: Patients who are unreliable in following physicians' directives; did not use of any other H1-receptor antagonists, steroids, or antiallergy agent within 48 hours before entry; have no history of contraindication of H1-receptor antagonist, Glycyrrhizic Acid injestion, or similar articles; are pregnant or in lactation period; have to drive back home by oneself; and are in other conditions at the discretion of the individual physician

Design outcomes

Primary

MeasureTime frame
A visual analog scale (VAS) for pruritus as a patient's subjective measurement

Secondary

MeasureTime frame
Evaluation of the itch based on a new rating scale (a 'itch score'), a final global improvement rating

Countries

Japan

Contacts

Public ContactHiromi Watanabe

Yuzawa Community Medical Center Community and family medicine

025-780-6543

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026