late-life depression
Conditions
Interventions
PET, MRI, Neuropsychology
PET, MRI, Neuropsychology
Sponsors
National Institute of Radiological Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients 1) Age, 60-84 years 2) Diagnosis, major depressive disorder as defined by the criteria of DSM-IV-TR 3) Subjects who have the ability to provide informed consent Inclusion criteria for normal controls 1) Age, 60-84 years 2) Mini-mental state examination score, >23 points 3) No current or past history of psychiatric disorders and no current medical conditions 4) Subjects who have the ability to provide informed consent 5) Subjects who are judged by researchers as suitable for participation in the study
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients 1) Serious suicidal ideation or behavior 2) Mini-mental state examination score at screening, <=23 points 3) Co-morbid other psychiatric disorders including drug dependence 4) Existence of brain organic disease, including current or past history of cerebrovascular disease, Parkinson's disease, and other related disorders 5) Existence of serious medical illnesses 6) Subjects who are judged by researchers as not suitable for participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Findings of the comparison between depression patients and age- and gender-matched normal controls with regard to the following factors: PET study (serotonin-transporter binding, amyloid deposition, and glucose metabolism) Structural MRI Neuropsychology | — |
Secondary
| Measure | Time frame |
|---|---|
| Relationships between clinical symptoms or disease course and neuroimaging or neuropsychological tests | — |
Countries
Japan
Outcome results
None listed