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Controlled comparative study for the efficacy between famotidine and omeprazole on prevention of delayed bleeding from ulcer after ESD for early gastric cancer

Controlled comparative study for the efficacy between famotidine and omeprazole on prevention of delayed bleeding from ulcer after ESD for early gastric cancer - Effect of H2RA and PPI on prevention of bleeding after ESD for early gastric cancer

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-UMIN000001215
Enrollment
120
Registered
2008-06-30
Start date
2008-02-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

early gastric cancer

Interventions

Administration of famotidine 40mg P.O./day for 8weeks Administration of famotidine 40mg P.O./day for 1day and omeprazole 40mg I.V./day for 3days after ESD and omeprazole 20mg P.O./day for 7weeks and 4

Sponsors

Hyogo College of Medicine Upper gastroenterology Department of internal medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. early gastric cancer patients who undergo ESD 2. patients who are older than 20 years at entry. 3. patients who understand the study contents and give informed consents by themselves

Exclusion criteria

Exclusion criteria: 1. patients with severe liver, renal and cardiopulumonary diseases. 2. patients who took medicines described below within one week before the first day of the study; H2RA, PPI 3. patients who had underwent eradication therapy for H.pylori within 6 months before the first day of the study 4. patients who are pregnancy, in breast-feeding or who wish pregnancy during the study period. 5. patients who are regarded in-eligible by the doctor who participates in this study.

Design outcomes

Primary

MeasureTime frame
Retio of delayed bleeding(hematemesis or melena required endoscopic hemostasis, decreased the hemoglobin count by more than 2g/dl)

Secondary

MeasureTime frame
The curative rate for ulcer after ESD at 6 weeks later

Countries

Japan

Contacts

Public ContactYongmin Kim

Hyogo College of Medicine Upper gastroenterology Department of internal medicine

miwa-sec@hyo-med.ac.jp0798-45-6665

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026