Treatment of Keloids and Hypertrophic Scars with a Long-pulsed Nd:YAG Laser in non-contact mode

Treatment of Keloids and Hypertrophic Scars with a Long-pulsed Nd:YAG Laser in non-contact mode - Treatment of Keloids and Hypertrophic Scars with a Long-pulsed Nd:YAG Laser in non-contact mode

Status

Active, not recruiting

Phases

Phase 1

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000001208

Enrollment

Registered

2008-12-31

Start date

2006-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

keloids and hypertrophic scars

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: The subjects were 22 Japanese patients (four males and 18 females) with a mean age of 34.95 years. Of these patients, 16 had keloids and six had hypertrophic scars. We defined keloids as scars that extended beyond the confines of the original wound.

Exclusion criteria

Exclusion criteria: none received any other treatment

Design outcomes

Primary

Measure	Time frame
The patients were treated every 3 to 4 weeks with the long-pulsed 1064-nm Nd:YAG laser (GenesisTM, Cutera Inc., Brisbane, CA, USA), which was applied in non-contact mode with a spot size that was 5 mm in diameter, an energy density of 14 J/cm2, an exposure time per pulse of 0.3 msec, and a repetition rate of 10 Hz. 500 to 1000 pulses per cm2. The frequency of irradiation ranged from 5 to 49 exposures and averaged 14.05 exposures. The response of the scars to the laser treatment was assessed by measuring the following five parameters: color, degree of hypertrophy, hardness of hypertrophy, itching, spontaneous pain, and tenderness. The assessments were performed by two experienced physicians (S.K. and R.O.) before the treatments started and after they were completed. Scoring was based on a 4-point scale ranging from 0 to 3 (0 = absent; 1 = mild; 2 = moderate; 3 = severe. In other words, the maximum possible score for a patient was 15 points.	—

Measure

Time frame

The patients were treated every 3 to 4 weeks with the long-pulsed 1064-nm Nd:YAG laser (GenesisTM, Cutera Inc., Brisbane, CA, USA), which was applied in non-contact mode with a spot size that was 5 mm in diameter, an energy density of 14 J/cm2, an exposure time per pulse of 0.3 msec, and a repetition rate of 10 Hz. 500 to 1000 pulses per cm2. The frequency of irradiation ranged from 5 to 49 exposures and averaged 14.05 exposures. The response of the scars to the laser treatment was assessed by measuring the following five parameters: color, degree of hypertrophy, hardness of hypertrophy, itching, spontaneous pain, and tenderness. The assessments were performed by two experienced physicians (S.K. and R.O.) before the treatments started and after they were completed. Scoring was based on a 4-point scale ranging from 0 to 3 (0 = absent; 1 = mild; 2 = moderate; 3 = severe. In other words, the maximum possible score for a patient was 15 points.

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Countries

Japan

Contacts

Public ContactSatoshi Akaishi

Nippon Medical School Hospital Plastic, Reconstructive and Aesthetic Surgery

redstoneprs@gmail.com03-3822-2131

Outcome results