Joint repair using an in vitro generated scaffold-free tissue engineerd construct (TEC) derived from autologous synovial mesenchymal stem cells

Joint repair using an in vitro generated scaffold-free tissue engineerd construct (TEC) derived from autologous synovial mesenchymal stem cells - Joint repair by tissue engineerd construct (TEC)

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001195

Enrollment

Registered

2008-07-01

Start date

2009-12-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chondral lesions Meniscal lesions

Interventions

Implantation of in vitro generated mesenchymal stem cell (MSC)-based tissue engineered construct (TEC) to chondral or meniscal lesions of the knee.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with a symptomatic (including pain, catching, locking, or joint effusion) chondral or meniscal lesion of the knee which is clinically detectable by MRI

Exclusion criteria

Exclusion criteria: Patients with 1) Active local infection 2) Serious complications including malignancies 3) Alchol or drung abuse 4) Rheumatoid arthritis, gout, or pseudo gout 5) Abnormal alignment of lower extremity 6) Chondral lesion with more than 5cm2 7) Meniscal lesion with large defect more than one-third of whole meniscal body 8) Patello-femoral instability 9) Diabetes 10) Renal failure which requires dialysis 11) the medication which could affect chondral metabolosm such as vitamin C or hyaluronan 12) Infectious disease (HIV, HBV, HCV, HTLV, syphilis) 13) Pregnancy 14) Allergy 15) participation in other clinical trials 16)Judged inappropriate with other reason by the project investigators

Design outcomes

Primary

Measure	Time frame
Adverse events (National Cancer Institute-Common Toxicity; NCI-CTC; version 2, JACOG version) Arthoscopic assessment of repaired tissue using ICRS evaluation package (http://www.cartilage.org) for chondral lesions and Horibe score (J Bone Joint Surg Br. 1995; 77:245-9) for meniscal lesions.	—

Secondary

Measure	Time frame
Periodical assessment of clinical symptoms, evaluation by MRI, histology, activity scales (Lyshlom, Tegnar), and by overall subjective assessment score (Knee Injury and Osteoarthritis Outcome Score; KOOS)	—

Countries

Japan

Contacts

Public ContactNorimasa Nakamura

Osaka University Center for Advanced Medical Engineering and Informatics

06-6879-3552

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026