Randomized controlled trial to compare cyclosporine and tacrolimus for GVHD prophylaxis after unrelated bone marrow transplantation

Randomized controlled trial to compare cyclosporine and tacrolimus for GVHD prophylaxis after unrelated bone marrow transplantation - RCT to compare CsA and FK506 for GVHD prophylaxis after unrelated BMT

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001151

Enrollment

110

Registered

2008-05-12

Start date

2008-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acute leukemia or myelodysplastic syndrome

Interventions

cyclosporine tacrolimus

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged between 16 and 55 years old with acute leukemia or myelodysplastic syndrome who undergo unrelated BMT

Exclusion criteria

Exclusion criteria: Uncontrolled DM, HTN, and so on.

Design outcomes

Primary

Measure	Time frame
Success difined as 1) alive at day 100, 2) absence of grade II-IV acute GVHD, 3) discontinuation of assigned immunosuppressant, and 4) use of steroid.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026