Hypertension
Conditions
Interventions
Evening administration of angiotensin II receptor blocker (Candesartan)
Morning administration of angiotensin II receptor blocker (Candesartan)
Sponsors
Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Hypertensive patients with morning and/or evening home systolic blood pressure at least 135 mmHg
Exclusion criteria
Exclusion criteria: 1) Recent history (within 6 months) of ischemic heart disease, stroke (excluding transient ischemic attack), aortic dissection, and peripheral arterial disease. 2) History of admission due to heart failure 3) On hemodialysis 4) Chronic inflammatory disease (cancer, collagen disease) 5) Subjects who are difficult to get informed consent 6) Subjects who are unable to visit to hospitals/clinics 7) History of adverse effect with candesartan, and contraindications of candesartan 8) Atrial fibrillation 9) Bilateral renal arterial stenosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of home morning blood pressure Improvements of hypertensive target organ damage measured as urinary albumin excretion ratio and brain-type natriuretic peptide | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in 24-hr blood pressure Changes in left ventricular hypertrophy(electrocardiogram and echocardiography), left ventricular diastolic function, carotid intima-media thickness, pulse wave velocity, augmentation index and baroreflex sensitivity | — |
Countries
Japan
Contacts
Public ContactSatoshi Hoshide, Joji Ishikawa
JMS-TOP study coordinator Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medi
Outcome results
None listed