Effects of lipid lowering by atorvastatin on carotid atherosclerotic plaque (ACAP) study: a randomized trial for analysis of qualitative change in carotid atherosclerrotic plaque with IB echo and Black Blood MRI

Effects of lipid lowering by atorvastatin on carotid atherosclerotic plaque (ACAP) study: a randomized trial for analysis of qualitative change in carotid atherosclerrotic plaque with IB echo and Black Blood MRI - Atorvastatin on Carotid Atherosclerotic Plaque (ACAP) study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001114

Enrollment

100

Registered

2008-05-01

Start date

2006-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid artery stenosis

Interventions

Atorvastatin Diet

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1) Patients with mild hypercholesterolemia; TC<240mg/dL 2) Patients with carotid stenosis of 30 to 60% 3) Patients naive to lipid-lowering medications at the study enrollement

Exclusion criteria

Exclusion criteria: 1) Patients with a history of adverse effects or allergy to atorvastatin 2) Patients with a history of angina or miocardial infarction 3) Patients parformed carotid endartelectomy or carotid artery stenting before the entry of the study 4) Patients who are pregnant, possibly pregnant, or lactating 5) Patients judged inappropriate for this study by a physician

Design outcomes

Primary

Measure	Time frame
The property change in carotid artery plaque after three and six months using IB echo and Black Blood MRI.	—

Secondary

Measure	Time frame
1) The change of the serum lipid metabolism in six months: Serum total cholesterol, HDL cholesterol, LDL cholesterol, and triglycerides 2) The change of the inflammatory marker in six months: serum high sensitivity CRP 3) Ischemic attack in the territory of the internal carotid artery on the ipsilateral side	—

Countries

Japan

Contacts

Public ContactKiyofumi Yamada

Gifu University Graduate School of Medicine Department of Neurosurgery

kyamada@gifu-u.ac.jp058-230-6271

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026