idiopathic membranous nephropathy associated with nephrotic syndrome
Conditions
Interventions
Steroid group: Immunosuppressive therapy is started by predonisolone 0.8mg/kg/day (max 60mg/day). The dose is decreased by 5mg/day in 2 to 4 weeks after remission. The cases who do not reach remission
Sponsors
Division of Kidney and Dialysis, Department of Internal Medicine,Hyogo College of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The cases of idiopathic membranous nephropathy associated with nephrotic syndrome are included in this study. (Diagnosis is done under the criteria of research group of Ministry of Health, Labour and Welfare.) Written informed concent is needed.
Exclusion criteria
Exclusion criteria: The cases who are considered inappropriate under "Guideline of ciclosporin therapy in nephrotic syndrome" or each doctor's decisions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quantity of urinary protein, frequency of relapse, renal function (serum Cr, estimated GFR),time to remission, total dose of steroid (until remission) | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects of steroid and ciclosporin, total dose of steroid (in all treatment period), duration of hospitalization, serum albumin, serum total protein, serum total cholesterol, degree of edema | — |
Countries
Japan
Contacts
Public ContactMasaaki Izumi
Hyogo College of Medicine Division of Kidney and Dialysis, Department of Internal Medicine
Outcome results
None listed