Graves'
Conditions
Interventions
Only radioiodine therapy
Radioiodine therapy and inactive iodine 0.1 mg tid for 5 days
Radioiodine therapy and lithium carbonate 600 mg tid for 8 days
Sponsors
Hiroshima University Hospital Department of Endocrinology and Metabolism
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Graves' disease according to the guideline of the Japan Thyroid Association Patient who hoped for radioiodine treatment after enough explanation about risk and benefit of this therapy. Age>=19 years old when the consent is obtained. Possible to attend a hospital regularly about 24 weeks. No previous radioiodine therapy. Possible to obtain written informed consent.
Exclusion criteria
Exclusion criteria: Pregnancy, suspected pregnancy or who won't avoid pregnancy within one year. Nursing woman (possible when not nursing). Active Graves' ophthalmopathy (CAS ) or deterioration in eye symptoms in the preceding months Contraindication of inactive iodine and lithium carbonate. Any other reason for which the investigator judged the patient to be unfit for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients who achieved an euthyroid or hypothyroid at 24 weeks after radioiodine therapy : free T4 level of less than upper limit of normal | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients who achieved an euthyroid or hypothyroid at 24 weeks after radioiodine therapy : free T3 level of less than upper limit of normal and TSH level of more than lower limit of normal. Changes in thyroid volume from 0 to 1 and 24 weeks. Incidence and evaluation of adverse events | — |
Countries
Japan
Contacts
Public ContactKenji Oki
Hiroshima University Department of Molecular and Internal Medicine
Outcome results
None listed