Gastric cancer patients undergoing elective total gastrectomy
Conditions
Interventions
Ampicillin-sulbactam is administered after the induction of anesthesia, and the patients received an additional dose if the operation was prolonged beyond 3 hour, and Ampicillin-sulbactam was administ
Sponsors
Randomized clinical trial committee, Japan Society for Surgical Infection
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Gastric cancer patients undergoing elective total gastrectomy (up to D2 lymph node resection by Japanese classification and R0 resection by UICC TNM Classification).
Exclusion criteria
Exclusion criteria: Exclusion criteria are as follows. Receive thoracotomy or other organ resection. Laparoscopic (assisted) surgery. Cancer of the remnant stomach. Those who received steroid therapy or radiotherapy. Those who were allergic to beta lactumase inhibitor, pregnant, received antibiotic treatment in the past 2 weeks, had an infection at the time of surgery, had malignant disease of other organ. Those with cardiac dysfunction, liver dysfunction, renal dysfunction, severe diabetes mellitus, or ASA score >3.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to show that a 24 hours antibiotic administration of the end of the operation was not inferior to the 3 days antibiotic administration of the postoperative period. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is to investigate the incidence of remote infection in each group. | — |
Countries
Japan
Contacts
Public ContactMasato Kusunoki
Japan Society for Surgical Infection Chairman of randomized clinical trial committee
Outcome results
None listed