Study of SNPs effect of Cytochrome P450 and Vitamine K related enzyme on PK/PD of warfarine

Study of SNPs effect of Cytochrome P450 and Vitamine K related enzyme on PK/PD of warfarine - VK-SNPs-W

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000001058

Enrollment

300

Registered

2008-02-28

Start date

2008-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atrial fibrillarion, pulmonary embolism, deep vein thronbosis, heart failure, stroke and other cardiovascular diseases

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: those who treated by warfarin for a long term more than 6 months, and having underwent PT-INR evaluation for more than 6 time in this period

Exclusion criteria

Exclusion criteria: None.

Design outcomes

Primary

Measure	Time frame
To evaluate the difference between four groups defined by SNPs of P450 and vitamin K related enzyme with PK/PD of warfarin and vitamin K concentration in the blood.	—

Secondary

Measure	Time frame
To evaluate the difference between four groups defined by SNPs of P450 and vitamin K related enzyme with retrospectively collected warfarin PD data as long term therapy.	—

Countries

Japan

Contacts

Public ContactNaoki Matsumoto

St. Marianna University School of Medicine Department of Pharmacology

matsumoto@marianna-u.ac.jp044-977-8111

Outcome results