The effects of collagen and hyaluronic acid for osteoarthritis symptoms study (CHAOS study), OCU-0704

The effects of collagen and hyaluronic acid for osteoarthritis symptoms study (CHAOS study), OCU-0704 - CHAOS study, OCU-0704

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001027

Enrollment

100

Registered

2008-02-23

Start date

2008-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

Period: 48 weeks Intervention group: the examination food (pigskin extraction collagen peptide 90.2%, hyaluronic acid 0.3%, mucopolysaccharides 0.8%, and water 8.7%) is taken, 5g a day. Control grou

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Knee pain

Exclusion criteria

Exclusion criteria: artificial replacement of the knees, current use of NSAIDs, current use of steroid, rheumatoid arthritis patients, severe inflammation (ESR>=40mm/h or RF positive), intraarticular injection to the knees within 3 months, abnormal function of liver and kidney (2.5 times or more normal value), intake of alternative medicine (glcosamin, chondroitin sulfate, collagen, and hyaluronic acid) within 4 weeks, remarkable obesity (BMI>30), pregnant or nursing

Design outcomes

Primary

Measure	Time frame
WOMAC score, joint narrowing of the knee (MTP view), SF-36, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ)	—

Secondary

Measure	Time frame
Bone metabolic marker (BAP, NTx), cartilage metabolic marker (COMP)	—

Countries

Japan

Contacts

Public ContactHidekichi Tokai

Osaka City University Hospital Center for Drug & Food Clinical Evaluation

tokai@med.osaka-cu.ac.jp06-6645-3440

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026