Osteoarthrities
Conditions
Interventions
Sodium hyaluronate : Suvenyl
intra-articular injection 25mg
Loxoprofen : Roxonin
tablet 60mg
Sponsors
Research Group of Cartilage Metabolism
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: ;Ambulatory outpatients with knee pain, between the ages of 50 and 80 ;Regardless of gender, but in case of female, only postmenopausal patients ;Mild to moderate OA of the knee with Kellgren-Lawrence (K-L) grade of between land3 ;Patients who signed informed consent documents for the treatment and investigation protocol
Exclusion criteria
Exclusion criteria: ;Taken glucocorticoids (intra-articular injection, oral use, external use) within previous 4weeks ;Taken NSAIDs (oral, suppository, external) within previous 2weeks ;K-L grade of contralateral knee is 4 ;Secondary OA of the knee (eg. traumatic OA of the knee) ;Patellofemoral OA (K-L grade of more than 3) ;Moderate OA other than knee ;Rheumatoid arthritis ;Having history of total knee replacement or total hip replacement ;Having history of anaphylactoid reaction to sodium hyaluronan or loxoprofene ;Peptic ulcer ;Abnormal dysemia, abnormal hepatic function, abnormal kidney function, abnormal heart function ;Aspirin-induced asthma or its history ;.Inappropriate patients from the doctor's viewpoint
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of JKOM score from baseline. | — |
Countries
Japan
Contacts
Public ContactKunihiko Hayashi
central cordinating center Gunma univercity
Outcome results
None listed