Phase I study of preoperative Docetaxel, Cisplatin and S-1 for patients with advanced gastric cancer

Phase I study of preoperative Docetaxel, Cisplatin and S-1 for patients with advanced gastric cancer - Phase I study of preoperative DCS therapy for advanced gastric cancer

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000001025

Enrollment

Registered

2008-02-15

Start date

2007-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with unresectable gastric cancer due to limited invasion and/or metastasis.

Interventions

Docetaxel day 1, 15 Cisplatin dat 1, 15 S-1 80mg/m2 day 1-14 every 28 days for 2 cycles followed by gastrectomy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Histologically confirmed as gastric cancer 2. patients with unresectable advanced gastric cancer due to limited invasion and/or metastasis. 3. Age 20-75 4. PS 0-1 5. No prior therapy including chemotherapy, radiation and surgery. 6. Patients who can take medication orally. 7. Sufficient function of important organs. 8. Life expectancy > 8weeks 9. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Active infection 2. Other severe complications 3. Active double cancer 4. CNS metastasis 5. Pericardiac fluid 6. Mortor paralysis or peripheral neural disturbance. 7. History of severe allergy against drug. 8. Severe peritoneal metastasis 9. Pregnant women or women who like to be pregnant. 10. Doctor' s dicision not to be registered to this study.

Design outcomes

Primary

Measure	Time frame
Safety	—

Secondary

Measure	Time frame
Adverse events Ratio of complete treatment Response rate of preoperative chemotherapy	—

Countries

Japan

Contacts

Public ContactSachio Fushida

Kanazawa University Hospital Gastroenterologic Surgery

076-265-2362

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026