Xerostomia due to Sjogren`s syndrome
Conditions
Interventions
It is a gargle with a test drug(Cevimeline hydrochloride hydrate 30mg+Hachiazule(TM)gargle 2g+distilled water 50cc)for two minutes. wash out, It is a gargle with false placebo1 (Cevimeline hydrochlor
Sponsors
Department of Dentistry and Oral Surgery, Tochigi National Hospital
National Institute of Public Health
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: A gum test value is 10ml/10min excess. The person who does not have a feeling of xerostomia. The person who gets mutual understanding.
Exclusion criteria
Exclusion criteria: The person that a gargle is impossible. A person we have a history of sick treatment of facial nerve or is treating the present. A person we have a history of sick treatment of trigeminus or is treating the present. A person we have a history of salivary gland conditions treatment within six months before this agent administration start or is treating the present. A person of diabetes mellitus. A person having an extensive oral mucosa disorder. The person who took the medicine that it was thought that we had an influence on salivary secretion during taking again within examination one month. It is a hypersensitivity symptom and a person having contraindication in cevimeline hydrochloride hydrate and Hachiazule(TM) gargle. The pregnancy and a woman nursing or a woman with pregnant likelihood. In addition, the person who admitted that we were inappropriate though a study director performed the final examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is amount of increase in the unstimulated whole saliva secretion after gargle 90 minutes, gargle 60 minutes later, gargle 30 minutes later and gargle 15 minutes later. | — |
Countries
Japan
Contacts
Public ContactHiroshi Iwabuchi
Tochigi National Hospital Department of Dentistry and Oral Surgery
Outcome results
None listed