Patients undergoing elective rectal cancer surgery
Conditions
Interventions
Cefmetazole is administered afetr the induction of anesthesia, and the patients recieved an additional dose if the operation was prolonged beyond 3 hour, and cefmetazole was administered agin twice da
Sponsors
Randomized clinical trial committee, Japan Society for Surgical Infection
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients undergoing elective rectal cancer surgery which is R0 resection (UICC TNM Classification).
Exclusion criteria
Exclusion criteria: The exclusion criteria were a bowel obstruction or stenosis, reconstruction of stoma before rectal resection, laparoscopic surgery, combined resection with other organ, known allergy to a beta-lactam, treatment with any antibiotic within the past 2 weeks, pregnancy, and evidence of an infection at the time of surgery, ASA score more than 3, and recived preoperative chemoterapy and/or radiotherapy. Patients are also excluded if they had liver or cardiac, renal dysfunction, and if their physician decided unfit for this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is to show that a 24 hours antibiotic administarion of the end of the operation was not inferior to the 3 days antibiotic administration of the postoperative period . | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome is to investigate the incidence of remote infection in each group. | — |
Countries
Japan
Contacts
Public ContactMasato Kusunoki
Japan Society for Surgical Infection Chairman of randomized clinical trial committee
Outcome results
None listed