Osteoporosis
Conditions
Interventions
None listed
Sponsors
National Hospital Organization, Kyoto Medical Center
National Hospital Organization, Saitama Hospital Tsuji Clinic Oishi Clinic Ogawa Clinic Kitani Clinic Taniguchi Clinic Tsukuda Clinic Higashimae Clinic Furukawa Clinic Furuke Clinic Wakabayashi Clinic
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Outpatients fullfilling the following 1) or 2) and 3) criteria 1)patients in which bone mineral density or femoral neck bone determined by DXA method is less than 70% of the young adult mean (YAM) 2)patients in which bone mineral density or femoral neck bone by DXA method is between 70% and 80% (1) postmenopausal female or (2) male patients with at least one of the following risks: excess alcohol drinking (more than 2 units/day), present smoking habit, or family history of femoral neck bone fracture 3)aged between 50 years and 85 years
Exclusion criteria
Exclusion criteria: 1) patient taking bisphosphonates 2) patients contraindicated for alendronate 3) patients under treatment of glucocorticoid or with a history of treatment for 3 years or more. 4) disease states causing secondary osteoporosis: primary hyperparathyroidism, hyperthyroidism, hypogonadism, chronic rheumatic arthritis, multiple myeloma and other hematological diseases,Cushing's syndrome, immobilization, mesotholexate 5) type I diabetes mellitus, diabetes associated with other specific diseases and pregnancy 6) patients not suitable for measuring bone mineral density due to the history of supine bone fracture 7) other various conditions in which the attending doctor decide not suitable for entry.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first outcome is the effects of long-acting alendronate on the osteoporosis and the second outcome is the comparison of the effects between the patients with and without impaired glucose metabolism | — |
Countries
Japan
Contacts
Public ContactMitsuhide Naruse
National Hospital Organization, Kyoto Medical Center Department Endocrinology, Clinical Research Institute for Endocrine and Metabolic Diseases
Outcome results
None listed