Erectile and endothelial dysfunction are common pathologies of multiple cardiovascular risk factors and are considered longitudinal predictors of cardiovascular events. Oxidative stress and decreases in testosterone levels play an important role in the pathogenesis of endothelial dysfunction.
Conditions
Interventions
Regular intake of Sildenafil 50mg once a week
Regular intake of Tadanafil 20mg once a week
Sponsors
Teikyo University, School of Medicine, Department of Urology
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: ED patients whose IIEF-scores are less than 17.Inclusion criteria included married with stable sexual relations with a female partner for at least 6 months before the study, as well as no previous treatment for ED.
Exclusion criteria
Exclusion criteria: Subjects with kidney disease, liver failure, coronary heart disease, peripheral or cerebrovascular disease, endocrine diseases, prostatic disease, and major psychiatric disorders, except depression, were excluded. Patients concomitantly treated with nitrates or with congestive heart failure or those who were prescribed medicines that might modulate testosterone metabolism were also excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| IIEF-EF scores are used to assess ED severity. Antioxidant status is defined by salivary 8-OHdG. Salivary testosterone is used to evaluate serum bioavailable testosterone availability. | — |
Countries
Japan
Outcome results
None listed