gastroesophageal reflux disease
Conditions
Interventions
omeprazole 10mg qd after breakfast for 4 weeks
omeprazole 10mg qd after breakfast plus mosapride 5mg tid for 4 weeks
Sponsors
Department of Gastroenterology, The University of Tokyo Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patient who fills everything the following 1)Patient with GERD(erosive and nonerosive) 2)Patient of 20 years or more 3)Patient who gives written informed consent 4)Outpatient and in-patient
Exclusion criteria
Exclusion criteria: The patient who collides with either the following assumes that it doesn't put it in to the examination 1)Patient with gastric or duodenal ulcer 2)Patient with malignant neoplasm, diabetes or thyroid disease 3)Patient who has severe liver disease.(AST(GOT) or ALT(GPT) is 100 U or more ) 4)Patient who has severe renal dysfunction(BUN 25mg/dL or more or serum creatinine 2.0 mg/dL or more) 5)Patient who has the pasts of digestive tract operations other than appendectomy 6)Patient who took medicine that influences movement and function of digestive tract such as proton pump inhibitor, H2 blocker, and NSAIDs within 4 weeks 7)Alcohol or drug abuse 8)Pregnant females and lactating women 9)Patient whom examination doctor judged improper as testee
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary efficacy endpoint is improvement in the FSSG(Frequency Scale for the Symptoms of GERD).The FSSG was performed before the study.After 4 weeks of therapy with either regimen, FSSG was performed again.The levels of the improvement of the GERD symptom are compared in omeprazole and omeprazole plus mosapride . | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.GSRS score after 4 weeks 2.FSSG score stratified by nonerosive GERD and erosive GERD | — |
Countries
Japan
Outcome results
None listed