Clinical study of Landiolol hydrochloride in the treatment of postoperative atrial fibrillation/atrial flutter after cardiovascular surgery

Clinical study of Landiolol hydrochloride in the treatment of postoperative atrial fibrillation/atrial flutter after cardiovascular surgery - JL-Knight Study (Japan Landiolol-Kicking off the novel investigation for gold standard heart study)

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000957

Enrollment

400

Registered

2007-12-27

Start date

2008-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tachyarrhythmia

Interventions

Intravenous beta-blocker, Landiolol hydrochloride for up to 24 hrs Intravenous calcium channel blocker, Diltiazem hydrochloride for up to 24 hrs

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients after cardiovascular surgery *postoperative atrial fibrillation / atrial flutter with a ventricular rate more than or equal to 110 b.p.m. for a duration more than or equal to 5 min within 7 days after surgery

Exclusion criteria

Exclusion criteria: (1) acute myocardial infarction within 3 days (2) supraventricular arrhythmia (3) sick sinus syndrome (containing patients with pacemaker) (4) grave heart failure (preoperative NYHA Classification of the Stages of Heart Failure, more than or equal to third degree) (5) atrioventricular block, more than or equal to second degree (6) contraindication to beta-blockers or , calcium channel blockers (7) electrolyte imbalance, WPW syndrome or hyperthyroidism (8) blood pressure < 90/60 mmHg (9) postoperative peroral use of beta-blockers or, calcium channel blockers (10) use of operative and postoperative antiarrhythmic medications excluding Digitalis

Design outcomes

Primary

Measure	Time frame
Atrial fibrillation / atrial flutter (heart rate control, converting rate to normal sinus rhythm, palindromia rate)	—

Secondary

Measure	Time frame
Ischemic changes Changes of blood pressure Manifestation rate of bradycardia,atrioventricular block and cardiovascular events Length of ICU and hospitalization Cost of medical care after cardiovascular surgery Mortality rate in nosocomial	—

Countries

Japan

Contacts

Public ContactChol Kim

Nippon Medical School Department of Anesthesiolgy

kim-nms@umin.net03-5814-6243

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026