Tachyarrhythmia
Conditions
Interventions
Landiolol hydrochloride is continuously administered during the operation. Heart rate is maintained betweeb 60 and 80bpm.
Landiolol hydrochloride is not used regardless of any heart rate. If neces
Sponsors
The Intraoperative Landiolol for Intracranial Aneurysm Surgery Trials Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing ruptured intraclanial aneurysm surgery. 2. The interval from the onset of symptoms until the operation is less than 48 hours. 3.Heart rate is 90 or more beats per minute before the operation.
Exclusion criteria
Exclusion criteria: 1.Patients with a cardiogenic shock, congestive heart failure, or hypotension (systolic blood pressure less than 90 mmHg, more than 30 minutes) 2. Patients with a diabetic ketoacidosis, or serious metabolic acidosis(BE equal or less than -10) 3. Patients with an atrioventricular block (the degree of II or III) or sick sinus syndrome. 4. Pregnant. 5. Patients with preoperative poor neurological score(Hunt and Kosnik grade 5). 6. Patients with a renal failure or undergoing hemodialysis. 7. Patients with a severe hepatic insufficiency. 8. Patients with severe obesity(body mass index equal or more than 35). 9. Patients with an immunodeficiency or medicated with the immunosuppressant. 10. Patients with an infection, such as a hepatitis B virus, a hepatitis C virus or human immunodeficiency virus, before the operation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of cardiovascular event | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate Plasma cytokine Markers of tissue damage (blood nitrotyrosine, urine 80HdG, S100-beta) Incidence of delayed ischemic neuronal deficits Neurological prognosis after three months | — |
Countries
Japan
Contacts
Public ContactMasahiko Kawaguchi
Nara Medical University Department of Anesthesiology
Outcome results
None listed