normal-tension glaucoma
Conditions
Interventions
None listed
Sponsors
Keio University School of Medicine,Department of Ophthalmology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Consecutive patients with newly diagnosed untreated normal tension glaucoma attending the Glaucoma clinic of Keio University Hospital.All subjects underwent a complete ophthalmic examination including best corrected visual acuity measurements, slit lamp biomicroscopy, pentacam corneal thickness evaluation (Oculus Inc, Germany), Goldmann applanation tonometry, gonioscopy, funduscopy, and optic disc evaluation with a 90-diopter lens (Zeiss, Tokyo, Japan). In addition, Humphrey visual field testing was conducted with a Humphrey field analysis using the 30-2 Swedish Interactive Threshold Algorithm Standard Strategy (Zeiss, Tokyo, Japan).Definite normal-tension glaucoma cases were required to meet the following criteria: 1)angles were open and not occludable in both eyes on the basis of gonioscopy, 2)visual field defects were present and consistent with glaucomatous optic neuropathy in the visual field tests, 3)All the IOPs measured by goldmann applanation tonometry at least twice at the day time were under 21 mmHg.
Exclusion criteria
Exclusion criteria: Subjects with other ophthalmic conditions such as angle closure glaucoma, pigment dispersion glaucoma, exfoliative glaucoma, trauma, any other type of secondary glaucoma, subjects with high myopia exceeding -10D or hyperopia below +3D, subjects below 40 or over 85 years of age, were excluded. None of these patients and controls had been taking steroids or immunosupressive agents. Other exclusion criteria for both groups were smoking and a history of any chronic systemic disease including diabetes mellitus, hypertension and auto-immune disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| opticlal density unit measured by ElISA for C.pneumoniae antigen | — |
Countries
Japan
Outcome results
None listed