Hypertension
Conditions
Interventions
Candesartan 4-12 mg po qd
Nifedipine XL 10-40 mg po qd
Sponsors
Department of Internal Medicine, School of Medicine, Keio University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients satisfying all the following criteria will be included in the study: 1.Age 30 to 59 2.Family history of hypertension (within 2 degrees) 3.Diagnosed with mild hypertension according to JSH 2004 guidelines (SBP of 140-159 mmHg and DBP of 90-99 mmHg on two separate occasions), taking no hypertensive medications for the previous 3 months. 4.Agrees to the study with informed consent.
Exclusion criteria
Exclusion criteria: Patients satisfying any one of the following criteria will be excluded from the study: 1.Secondary hypertension 2.Diabetes mellitus (HbA1c values of 6.5% or greater) 3.Renal dysfunction (serum creatinine values of 2 mg/dl or greater) 4.Patients with a history of cardiovascular disease (stroke, transient ischemic attack, coronary heart disease, heart failure) 5.Patients with severe liver dysfunction 6.Patients with malignancies 7.Pregnant patients, or patients intending to be pregnant 8.Other patients judged to be inappropriate by the attending physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Antihypertensive drug withdrawal success rates | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Median duration of drug withdrawal 2. Changes in home and office BP values after drug withdrawal | — |
Countries
Japan
Contacts
Public ContactHiroyuki Sasamura
School of Medicine, Keio University Department of Internal Medicine
Outcome results
None listed