The Study of Throid and Iron-Sulfur states in CKD

The Study of Throid and Iron-Sulfur states in CKD - TIS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000000908

Enrollment

100

Registered

2007-11-28

Start date

2007-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic kidney disease (nondialyzed, dialyzed)

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)kidney disease, require medical care 2)Followed in the outpatient of our hospital and associated clinic 3)Expected survival time is more than 6 months 4)Aged 20 to 90 years 5)Fully informed consent was obtained

Exclusion criteria

Exclusion criteria: 1)Malignancy 2)Malnutrition 3)Active inflammatory or infectious disease 4)Uncontrollable diabetes mellitus 5)Abdominal ascites or pleural effusion 6)Pregnancy 7)Judged inappropriate for this study by the physicians

Design outcomes

Primary

Measure	Time frame
metabolism of sulfur amino acid, iron and vitamins. thyroid function. factors of atherogenesis.	—

Secondary

Measure	Time frame
samples: blood, urine, peritoneal effluent, hair. factors of metabolism of sulfur amino acids (homocystein, cystein), iron (ferritin, hepcidin, transporters), thiocyanate (cyanide, thiosufate, sulfate), thyroid function (T3/4, fT3/4, TSH, anti-thyroglobulin antibody, lipid), inflammation/oxidative stress (CRP, cytokines, peroxidase, MDA, ROS, GSH), markers of cell damage (growth factors, CA125), atherosclerosis (chest X ray, echo, ABI, PWV), cardiovascular events (cardiovascular death, renal failure, total death, admission), others (nutritional status, vitamins, vintage of dialysis, beta2-microglobulin, hemoglobin)	—

Measure

Time frame

samples: blood, urine, peritoneal effluent, hair. factors of metabolism of sulfur amino acids (homocystein, cystein), iron (ferritin, hepcidin, transporters), thiocyanate (cyanide, thiosufate, sulfate), thyroid function (T3/4, fT3/4, TSH, anti-thyroglobulin antibody, lipid), inflammation/oxidative stress (CRP, cytokines, peroxidase, MDA, ROS, GSH), markers of cell damage (growth factors, CA125), atherosclerosis (chest X ray, echo, ABI, PWV), cardiovascular events (cardiovascular death, renal failure, total death, admission), others (nutritional status, vitamins, vintage of dialysis, beta2-microglobulin, hemoglobin)

—

Countries

Japan

Contacts

Public ContactYukiko Hasuike

Hyogo College of Medicine Department of Internal Medicine, Division of Nephrology and Dialysis

jin@hyo-med.ac.jp0798-45-6521

Outcome results