The effects of sildenafil on the oxidative stress and testosterone level in patients with erectile dysfunction

The effects of sildenafil on the oxidative stress and testosterone level in patients with erectile dysfunction - Sildenafil on oxidative stress markers and testosterone

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000900

Enrollment

Registered

2007-11-19

Start date

2007-03-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with erectile dysfunction

Interventions

sildenafil

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: Inclusion criteria included married with stable sexual relations with a female partner for at least 6 months before the study, as well as no previous treatment for ED.

Exclusion criteria

Exclusion criteria: Subjects with kidney disease, liver failure, coronary heart disease, peripheral or cerebrovascular disease, endocrine diseases, prostatic disease, and major psychiatric disorders, except depression, were excluded. Patients concomitantly treated with nitrates or with congestive heart failure or those who were prescribed medicines that might modulate androgen metabolism were also excluded.

Design outcomes

Primary

Measure	Time frame
salivary 8-OHdG, salivary and serum testosterone,IIEF-EF score.	—

Secondary

Measure	Time frame
LH, FEH, SF-36 score	—

Countries

Japan

Contacts

Public ContactShigeo Horie

Teikyo University, School of Medicine Department of Urology

shorie@med.teikyo-u.ac.jp03-3964-2497

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026