Case-control association study to identify key single nucleotide polymorphisms (SNPs) of cardio-renal association in type 2 diabetes.

Case-control association study to identify key single nucleotide polymorphisms (SNPs) of cardio-renal association in type 2 diabetes. - SNPs of Cardio-Renal Association in Type 2 Diabetes: SOCRATES

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000000889

Enrollment

300

Registered

2007-11-14

Start date

2007-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic kidney disease (CKD) due to type-2 diabetes mellitus

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Type 2 diabetic patients who have newly entered maintenance hemo-dialysis after at least 10 years duration of DM. Absence of diabetic retinopathy can be included.

Exclusion criteria

Exclusion criteria: Newly entered HD patients due to benign nephroscrelosis, nephritis, hereditary renal disease and type 1 DM. Deaths within 3 months of starting dialysis. Patients who do not need dialysis any more due to recovery of renal function. Peritoneal Dialysis. Patients who are planning to undertake living kidney transplantation. Patients with malignant tumors, liver cirrhosis, immuno-deficiencies, collagen diseases and severe mental disorders.

Design outcomes

Primary

Measure	Time frame
Study 1) Of all the patients entered, compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of patients with history of CVD complications at 3 months after starting hemodialysis. Control consists of those without. Study 2) Compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of the patients entered to this study. Control consists of type-2 diabetic patients who do not excrete proteinuria despite more than 10-years duration of DM among the cohort we have previously collected. In the control group, age, gender and duration of disease are matched to the case. Study 3) Among the patients entered, compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of patients with CVD complications (including both death and hospitalization) at 3 years after starting hemodialysis. Control consists of those without.	—

Measure

Time frame

Study 1) Of all the patients entered, compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of patients with history of CVD complications at 3 months after starting hemodialysis. Control consists of those without. Study 2) Compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of the patients entered to this study. Control consists of type-2 diabetic patients who do not excrete proteinuria despite more than 10-years duration of DM among the cohort we have previously collected. In the control group, age, gender and duration of disease are matched to the case. Study 3) Among the patients entered, compare the frequency of the gene polymorphisms between the case group and the control group. Case consists of patients with CVD complications (including both death and hospitalization) at 3 years after starting hemodialysis. Control consists of those without.

—

Secondary

Measure	Time frame
Only in the study 3, secondary outcomes are; total hospitalizations, total deaths, occlusions of arteriovenous fistula (AVF), cardio thoracic rate (CTR), and natriuretic peptides.	—

Countries

Japan

Contacts

Public ContactYoshiyuki Furumatsu

Osaka University Graduate School of Medicine Nephrology

furumatsu@yahoo.co.jp06-6879-3632

Outcome results