Randomized controlled trial of efficacy and safety of pre-operative GnRH agonist administration for laparoscopic myomectomy.

Randomized controlled trial of efficacy and safety of pre-operative GnRH agonist administration for laparoscopic myomectomy. - Effect of GnRHa for LM

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000879

Enrollment

100

Registered

2008-01-01

Start date

2006-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

uterine fibroid

Interventions

leuprorelin acetate 1.88mg/month no administration of GnRHa

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: maximam diameter of largest fibroid present:>5cm but<=7cm number of fibroids present that are greater than 5cm:<=3

Exclusion criteria

Exclusion criteria: Patients with a history of hypersensitivity to ingerdients of the investigational drug or to any synthetic LH-RH agent or LH-RH derivative Women sho are or potentially may be pregnant Lactating women Women with non-diagnosable, abnormal bleedng of unknown origin

Design outcomes

Primary

Measure	Time frame
The rate of myomas at 6 months after GnRHa administration. The side effects during GnRHa administration. The estimated bleeding during operation, duration of operation and the weight of extracted specimens.	—

Secondary

Measure	Time frame
The recurrence rate evaluated by MRI after LM. Pregnancy outcome after LM.	—

Countries

Japan

Contacts

Public ContactIwaho Kikuchi ,MD

Juntendo univ. school of medicine OB/GY

kikuchi@med.juntendo.ac.jp03-3813-3111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026