Skip to content

Elevated Plasma Level of CD144-Positive Endothelium-Derived-Microparticles Predicts Future Cardiovascular Events in Patients at High-Risk for Coronary Artery Desease

Elevated Plasma Level of CD144-Positive Endothelium-Derived-Microparticles Predicts Future Cardiovascular Events in Patients at High-Risk for Coronary Artery Desease - KUMAMOTO EMPs STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
JPRN
Registry ID
JPRN-UMIN000000876
Enrollment
500
Registered
2007-11-02
Start date
2003-05-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients at high-risk for coronary artery disease

Interventions

None listed

Sponsors

Graduate School of Medical Sciences, Kumamoto University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients at high risk for CAD. High risk for CAD was defined as having more than 2 factors of following; age 65 years or older; current smoking; hypertension (140/90 mmHg or more, or taking any antihypertensive medications); dyslipidemia (high density lipoprotein [HDL] cholesterol less than 40mg/dl, low-density lipoprotein [LDL] cholesterol 140mg/dl or more, or triglycerides 150mg/dl or more); diabetes mellitus; body mass index (BMI) 25.0 kg/m2 or more; family history of ischemic heart disease. Patient with stable CAD or history of old myocardial infarction (OMI) were also enrolled

Exclusion criteria

Exclusion criteria: The exclusion criteria for the study were severe valvular heart disease requiring surgical intervention, plan for coronary revascularization, active infection, and malignant disease. Patients with ACS were also excluded because they had a significantly higher cardiovascular event ratio than that of stable CAD patients.

Design outcomes

Primary

MeasureTime frame
The end points were any of cardiovascular death, nonfatal myocardial infarction, unstable angina, fatal or nonfatal ischemic stroke, or coronary revascularization to new lesions.

Countries

Japan

Contacts

Public ContactSeigo Sugiyama

Graduate School of Medical Sciences, Kumamoto University Department of Cardiovascular Medicine

ssugiyam@kumamoto-u.ac.jp096-373-5175

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026