Prospective Observational Survey on the Long-Term Effects of the LDL-Apheresis on the Drug Resistant Nephrotic Syndrome

Prospective Observational Survey on the Long-Term Effects of the LDL-Apheresis on the Drug Resistant Nephrotic Syndrome - Prospective Observational Survey on the Thrapeutic Effects of the LDL-Apheresis on the Drug Resistant Nephrotic Syndrome - POLARIS Survey -

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

JPRN

Registry ID

JPRN-UMIN000000871

Enrollment

200

Registered

2007-11-01

Start date

2007-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Refractory (drug resistant) nephrotic syndrome

Interventions

None listed

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who satisfy the criteria for refractory nephrotic syndrome (according to the report of the research and surveillance group for specified diseases, progressive renal impairment, the Ministry of Health, Labor and Welfare) and to whom the doctor in charge applied LDL-apheresis therapy on the basis of the guideline of the therapy for focal segmental glomerulosclerosis

Exclusion criteria

Exclusion criteria: not applicable

Design outcomes

Primary

Measure	Time frame
Rate of clinical improvement (total number of the complete remission and the type I incomplete remission)	—

Secondary

Measure	Time frame
Correlation between the rate of clinical improvement and the following factors which could influence the therapeutic effect 1. stage of nephritic syndrome 2. age 3. severity of renal lesion 4. severity of glomerulosclerosis, degree of tubular damage, selectivity index, etc. 5. TAT (blood coagulation marker) level 6. period between the onset of nephritic syndrome and the application of LDL-application 7. frequency of LDL-apheresis 8. dose of steroids used in combination with LDL-apheresis 9. presence or absence of steroid pulse during LDL-apheresis	—

Measure

Time frame

Correlation between the rate of clinical improvement and the following factors which could influence the therapeutic effect 1. stage of nephritic syndrome 2. age 3. severity of renal lesion 4. severity of glomerulosclerosis, degree of tubular damage, selectivity index, etc. 5. TAT (blood coagulation marker) level 6. period between the onset of nephritic syndrome and the application of LDL-application 7. frequency of LDL-apheresis 8. dose of steroids used in combination with LDL-apheresis 9. presence or absence of steroid pulse during LDL-apheresis

—

Countries

Japan

Contacts

Public ContactEri Muso

Kitano Hospital, The Tazuke Kofukai Medical Research Institute Division of Nephrology and Dialysis

polaris2001polaris@yahoo.co.jp06-6312-8824

Outcome results