Preliminary clinical study of a novel oral mucosal protective solution containing trehalose. &#8211;Alleviation of oral dryness caused during dental surgery&#8211;

Preliminary clinical study of a novel oral mucosal protective solution containing trehalose. &#8211;Alleviation of oral dryness caused during dental surgery&#8211; - Preliminary clinical study of a novel oral mucosal protective solution containing trehalose.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000866

Enrollment

Registered

2007-10-29

Start date

2007-11-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients recieving root canal treatment

Interventions

Patients recieving several root canal treatments will initially undergo the normal root canal treatment. In the next treatment, trehalose solution will be used.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Patients recieving several root canal treatments. 2.Patients willing and able to comply with the protocol and to give written informed consent . 3.Patients who have signed the IRB-approved written informed consent prior to the patient screening.

Exclusion criteria

Exclusion criteria: 1. Patients who declared diabetes at the interview prior to the study and are judged to be ineligible by doctors. 2. Patients who need special care for safety in usual dental therapy and are judged to be ineligible by doctors. 3. Patients who are judged to be inappropriate for the study by doctors in their charge

Design outcomes

Primary

Measure	Time frame
Subjective evaluation of dryness, pain, discomfort by the patient and of tongue dryness and papilla atrophy by the doctor	—

Countries

Japan

Contacts

Public ContactYoshiyuki Mori

The University of Tokyo Hospital Department of Oral-Maxillofacial Surgery, Dentistry and Orthodontics

mori-ora@h.u-tokyo.ac.jp03-5800-8669

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026

Preliminary clinical study of a novel oral mucosal protective solution containing trehalose. &amp;#8211;Alleviation of oral dryness caused during dental surgery&amp;#8211;