Multi-centric randomized open-label comparative study for influence of bisphosphonate on fracture healing in patients with spinal compression fractures or femoral neck fractures

Multi-centric randomized open-label comparative study for influence of bisphosphonate on fracture healing in patients with spinal compression fractures or femoral neck fractures - Influence of bisphosphonate on spinal compression fractures or femoral neck fractures

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000838

Enrollment

100

Registered

2007-10-01

Start date

2007-10-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporotic spinal compression fractures and femoral neck fractures

Interventions

Sodium risedronate hydrate was given from 1 week after injury or surgery in group A. Sodium risedronate hydrate was given from 3 months after injury or surgery in group B.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Inclusion criteria are primary osteoporosis patients with the age of 65 to 90 years old, osteoporotic spinal compression fractures, and osteoporotic femoral neck fractures.

Exclusion criteria

Exclusion criteria: Exclusion criteria are patients treated with bisphosphonate within 3 months, fractures resulted from high energy trauma, patients contraindicant to bisphosphonate, and patients judged inadequate to include this study by doctors.

Design outcomes

Primary

Measure	Time frame
Fracture healing is assessed with X ray film and computed tomograhy, and QOL is assessed with questionnaires.	—

Secondary

Measure	Time frame
Bone mineral density, visual analogue scale and bone markers are measured.	—

Countries

Japan

Contacts

Public ContactTakahiro Iida

Dokkyo Medical University Koshigaya Hospital Department of Orthopaedic Surgery

takiida@dokkyomed.ac.jp048-965-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026