A competitive acetate-free bicarbonate dialysate and standard bicarbonate dialysate of iron metabolism dysregulation improvement and cytokine production chilling of hemodialysis patients : a cross-over multicenter study.

A competitive acetate-free bicarbonate dialysate and standard bicarbonate dialysate of iron metabolism dysregulation improvement and cytokine production chilling of hemodialysis patients : a cross-over multicenter study. - Prospective Clinical Cross-over Study of Citrate Containg Dialyzate in hemodialysis patients. (CROCIT study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000773

Enrollment

Registered

2007-07-30

Start date

2007-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients, who are treated with maintenance hemodialysis more than one year

Interventions

one year in a 4-month cross-over study. first stage : hemodialysis treatment with standard bicarbonate dialysate. (acetate-containing) second stage: hemodialysis treatment with acetate-free bicarbon

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (i) Patients with maintenance hemodialysis (age less than 75 years old). (ii) Patients, whose duration of hemodialysis more than one year, and their hemodynamic state are stable. (iii) Patients, who are received hemodialysis 3 times a week and 4 hours at a time. (iv) Patients with renal anemia, who are treated with rHuEPO or iron.

Exclusion criteria

Exclusion criteria: (i) Patients with chronic inflammation (CRP over 0.3), malignant disorder, severe respiratory organs, and liver disorder. (ii) Patients, who are recived dialysis treatment except HD such as HF, HDF, and HDF.

Design outcomes

Primary

Measure	Time frame
(i) dosages of rHuEPO and iron. (ii) improvement of QOL . (iii) iron-related index , inflammation, nutrition, oxidative stress, endthelial injury.	—

Countries

Japan

Contacts

Public ContactTakahiro Kuragano

Hyogo College of Medicine Internal Medicine (Nephrology and Dialysis)

kuragano@hyo-med.ac.jp0798-45-6111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026