Phase I Radiation Dose Escalation Study using Four-dimensional Intensity Modulated Radiation Therapy for Locally Advanced Pancreatic Cancer

Phase I Radiation Dose Escalation Study using Four-dimensional Intensity Modulated Radiation Therapy for Locally Advanced Pancreatic Cancer - 4DIMRT-PI for LA-Pancreatic Cancer

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000745

Enrollment

Registered

2007-06-21

Start date

2007-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Locally advanced pancreatic cancer

Interventions

Radiation dose escalation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Written informed consent 2. Age <= 80 years old 3. KPS >= 70 4. No previous Tx for pancreatic cancer 5. Possible oral intake 6. No major systemic organ problem 7. UICC Stage III

Exclusion criteria

Exclusion criteria: 1. Gastric pr duodenal ulcer 2. Use of phenitoin, walfalin potasium, flusitosin 3. Plural effusion, ascitis 4. Active infection 5. Major comorbidities 6. Congnitive deterioration 7. Allegy to drug 8. Pregnancy 9. If doctor judged not feasible to enroll

Design outcomes

Primary

Measure	Time frame
Dose limiting toxicities GI toxicities Hematologic toxicities	—

Secondary

Measure	Time frame
Survival Local control Response rate Time to develop metastases	—

Countries

Japan

Contacts

Public ContactHidefumi Aoyama

Hokkaido University Hospital Radiology

011-716-1161

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026